Evidence Library

Publications & Scientific Evidence

Every ID Labs product page links to the central publications library. Access types are shown transparently — open-access PDFs are hosted where legally permitted; otherwise we provide citations, DOI and PubMed links.

WHO Consolidated Guidelines on Tuberculosis: Module 3 — Diagnosis: Rapid Diagnostics for Tuberculosis Detection

World Health Organization

WHO Guidelines · 2021 (updated)

GuidelineExternal link only

WHO recommendations on rapid molecular diagnostics for TB, including Xpert MTB/RIF and line probe assays, and their place within diagnostic algorithms. These are international guidelines; they do not constitute ID Labs validated performance data.

Rapid Molecular Detection of Tuberculosis and Rifampin Resistance

Boehme CC, Nabeta P, Hillemann D, et al.

New England Journal of Medicine · 2010 · Vol 363 · (11) · pp. 1005–1015

Clinical StudyExternal link only

Multicentre evaluation of the Xpert MTB/RIF assay demonstrating rapid, sensitive detection of tuberculosis and rifampicin resistance directly from sputum, compared with smear microscopy and culture.

Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock

Kumar A, Roberts D, Wood KE, et al.

Critical Care Medicine · 2006 · Vol 34 · (6) · pp. 1589–1596

Clinical StudyExternal link only

Landmark study showing that each hour of delay in effective antimicrobial therapy after the onset of septic shock is associated with a measurable decrease in survival — the evidence base for rapid diagnostics in sepsis.

Multiplex PCR in the differential diagnosis of fever of unknown origin and acute febrile illness

Published Scientific Evidence (various authors)

Peer-reviewed literature

ReviewCitation only

The published literature supports syndromic multiplex PCR as a tool for the differential diagnosis of undifferentiated febrile illness, particularly where multiple treatable pathogens (dengue, malaria, enteric fever, rickettsioses, leptospirosis) present with overlapping clinical features. Specific assay performance is target- and platform-dependent. Full citations for this collection are being curated.

Rapid antimicrobial susceptibility testing from positive blood cultures: platform review

Microbiology Research (MDPI) · 2026

ReviewExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Clinical metagenomics with Oxford Nanopore for bloodstream infection: species ID and AMR prediction

The Lancet Microbe · 2025

Clinical StudyExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

MALDI Biotyper Sirius versus VITEK MS PRIME: identification concordance

Microbiology Spectrum (ASM) · 2025

Comparative StudyExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Evaluating the performance of common dengue serological assays (NS1/IgM)

LSHTM Research Online · 2025

Clinical StudyExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Nested PCR for Acanthamoeba keratitis: diagnostic accuracy

Scientific Reports (Nature) · 2025

Clinical StudyExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Genotypic and phenotypic strategies for rapid antimicrobial susceptibility testing

Antibiotics (MDPI) · 2024

ReviewExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Automated blood-culture systems (BacT/ALERT VIRTUO vs BACTEC FX400): comparative evaluation

Microbiology Spectrum (ASM) · 2024

Comparative StudyExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Quantitative CMV nucleic-acid testing for viral-load monitoring in transplant recipients

PMC (peer-reviewed review) · 2024

ReviewExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Fourth International Consensus Guidelines on the Management of CMV in Solid-Organ Transplantation

Transplantation · 2024

GuidelineExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Microfluidic real-time PCR for rapid diagnosis of infectious endophthalmitis

Journal of Ophthalmic Inflammation and Infection · 2024

Technical EvaluationExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Multiplex PCR meningitis/encephalitis panel on cerebrospinal fluid: diagnostic performance

Scientific Reports (Nature) · 2024

Clinical ValidationExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Rapid multiplex PCR for bloodstream infections: systematic review and meta-analysis

The Lancet eClinicalMedicine · 2024

Meta-analysisExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

BioFire FilmArray Meningitis/Encephalitis panel: clinical evaluation in CSF

Microbiology Spectrum (ASM) · 2024

Clinical StudyExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Multiplex PCR for tropical acute febrile illness and malaria co-infections in central India

Medical Research Archives (ESMED) · 2024

Clinical StudyExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Clinical evaluation of respiratory pathogen multiplex PCR panels

Frontiers in Medicine · 2023

Clinical StudyExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Seegene Allplex STI Essential Assay: diagnostic evaluation

Annals of Laboratory Medicine (PMC) · 2022

Clinical StudyExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Nanopore adaptive sampling for host depletion in clinical metagenomics

Briefings in Bioinformatics · 2022

Technical EvaluationExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Alinity m STI multiplex PCR (CT/NG/TV/MG): multicenter clinical evaluation

Journal of Laboratory Medicine · 2021

Clinical ValidationExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Multiplex real-time PCR for SARS-CoV-2, influenza A/B and RSV: analytical and clinical evaluation

Journal of Clinical Virology (PMC) · 2021

Analytical ValidationExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Xpert MTB/RIF and Xpert Ultra for pulmonary TB and rifampicin resistance: Cochrane review

Cochrane Database of Systematic Reviews · 2021

Meta-analysisExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

CLIA/ECLIA versus ELISA for infectious-disease serology screening: comparative performance

Indian Journal of Clinical Biochemistry (PMC) · 2019

Comparative StudyExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

WHO Technical Manual for Drug-Susceptibility Testing of M. tuberculosis (BACTEC MGIT 960)

World Health Organization · 2018

GuidelineExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Evaluation of line probe assays (MTBDRplus/MTBDRsl) in clinical specimens

Frontiers in Microbiology · 2018

Clinical StudyExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

Comparison of rapid tests and multiplex PCR for dengue, malaria and chikungunya in acute febrile illness

BMC Infectious Diseases · 2017

Comparative StudyExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

WHO policy guidance: Xpert MTB/RIF Ultra as an initial diagnostic test for TB

World Health Organization · 2017

GuidelineExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

MALDI-TOF Biotyper for bacterial identification: multicenter accuracy study

PLOS ONE · 2015

Clinical ValidationExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

GenoType MTBDRplus and MTBDRsl for detection of TB drug resistance: diagnostic accuracy

Scientific Reports (Nature) · 2015

Clinical ValidationExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

LightCycler SeptiFast multiplex PCR for bloodstream infection: meta-analysis

PLOS ONE · 2013

Meta-analysisExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.

BACTEC MGIT 960 liquid culture for TB drug-susceptibility testing: performance

BMC Infectious Diseases · 2012

Clinical ValidationExternal link only

Curated peer-reviewed / authoritative reference. Open the source link for the full text.